Check the size of the file "pagefile.sys". This is the virtual memory page, that allows multiple applications to run on your computer. Problem is, if any of those applications are a memory hog, pagefile.sys balloons in size accordingly.
Open Task manager, click on the tab marked "Performance", then click on the button marked "Resource Monitor...". It'll show you which processes are using lots of physical memory as well as virtual memory (the graph for this latter quantity is labelled "Commit Charge"). One typical memory hog is the process associated with Windows Update, usually listed as "wuauclt.exe" or similar. That one can chew up several gigabytes if you're not careful. If you need to curtail it, run "Services.msc", locate the Windows Update service, and click "Stop the service". Then, set it to manual updates only, and update only when there's a critical security issue to address. Otherwise, Windows Update will clutter your hard drive with gigabytes of worthless updates that don't actually do anything really useful on your computer.
Oh, and if you want an antivirus that's much more lightweight, go for Avast. My installation only uses 900 MB of space, not 65 gigabytes! It's a free download to boot.